Pharmaceutical and clinical aspects of parenteral lipid emulsions in neonatology. 2014 1:85–91.ĭriscoll DF, Bistrian BR, Demmelmair H, Koletzko B. Neonatal necrotizing enterocolitis: pathogenesis, classification, and spectrum of illness. Impact of a physiologic definition on bronchopulmonary dysplasia rates. Walsh MC, Yao Q, Gettner P, Hale E, Collins M, Hensman A, et al. Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants. Safety and efficacy of a lipid emulsion containing a mixture of soybean oil, medium-chain triglycerides, olive oil, and fish oil: a randomised, double-blind clinical trial in premature infants requiring parenteral nutrition. Tomsits E, Pataki M, Tölgyesi A, Fekete G, Rischak K, Szollár L. Growth and fatty acid profiles of VLBW infants receiving a multicomponent lipid emulsion from birth. Vlaardingerbroek H, Vermeulen MJ, Carnielli VP, Vaz FM, van den Akker CH, van Goudoever JB. Lipids in the intensive care unit: recommendations from the ESPEN Expert Group. 2018 177:723–31.Ĭalder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, et al. Inpatient outcomes of preterm infants receiving ω-3 enriched lipid emulsion (SMOFlipid): an observational study. Lipid needs of preterm infants: updated recommendations. Lapillonne A, Groh-Wargo S, Gonzalez CHL, Uauy R. Improved fatty acid and leukotriene pattern with a novel lipid emulsion in surgical patients. Grimm H, Mertes N, Goeters C, Schlotzer E, Mayer K, Grimminger F, et al. Effect of placental function on fatty acid requirements during pregnancy. ![]() Free radicals: emerging challenge in environmental health research in childhood and neonatal disorders. The precarious antioxidant defenses of the preterm infant. Update on oxygen radical disease in neonatology. Essential fatty acids in visual and brain development. ![]() Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE. ConclusionsĬompared with Intralipid, SMOF-LE was not associated with differences in mortality and major morbidities but was associated with lower odds of any retinopathy, cholestasis, and osteopenia and improved lipid tolerance. SMOF-LE group had lower odds of cholestasis, osteopenia, and lipid interruption, and reduced times to full feeds and to regain birthweight. Primary outcomes did not differ significantly between groups, although any retinopathy was significantly lower in the SMOF-LE group. ![]() Resultsīaseline characteristics between groups were comparable. Secondary outcomes were cholestasis, osteopenia, time to full feeds, and time to regain birthweight. Primary outcomes were mortality, chronic lung disease, severe retinopathy, infection, and necrotising enterocolitis. We conducted a pre-post comparative study of very-low-birth-weight neonates, dividing them according to lipid emulsion received: Intralipid (soy-based n = 680) or SMOF-LE ( n = 617). To examine the effectiveness of soybean oil-medium chain triglycerides-olive oil-fish oil lipid emulsion (SMOF-LE) on clinical outcomes of very-low-birth-weight neonates.
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